2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-G0014B
    Quetiapine sulfoxide hydrochloride
    Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine sulfoxide hydrochloride
  • HY-133779
    Gefitinib impurity 5
    		99.46%
    Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.
    Gefitinib impurity 5
  • HY-W103882
    2-(Benzhydrylsulfinyl)acetic acid
    		99.57%
    2-Benzhydrylsulfinylacetic acid (Modafinil acid) is the metabolite of modafinil.
    2-(Benzhydrylsulfinyl)acetic acid
  • HY-13318S1
    Oseltamivir acid-13C,d3
    Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections.
    Oseltamivir acid-<sup>13</sup>C,d<sub>3</sub>
  • HY-109054
    O-Demethyltramadol
    O-Demethyltramadol is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme.
    O-Demethyltramadol
  • HY-G0001A
    Lurasidone Metabolite 14283 hydrochloride
    		99.06%
    Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved agent for the treatment of schizophrenia.
    Lurasidone Metabolite 14283 hydrochloride
  • HY-156752
    Cyclosiversioside F 16,25-diacetate
    		99.68%
    Cyclosiversioside F 16,25-diacetate (Compound 6), a glycoside, is an alkaline hydrolysis product of Acetyl Derivative (Compound 2).
    Cyclosiversioside F 16,25-diacetate
  • HY-116016
    Etilevodopa
    		99.00%
    Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine.
    Etilevodopa
  • HY-12770
    Mebeverine alcohol
    		99.61%
    Mebeverine alcohol is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
    Mebeverine alcohol
  • HY-115354
    4-Hydroxy alprazolam
    4-Hydroxy alprazolam is a metabolite of Alprazolam. Alprazolam is metabolized primarily by hepatic microsomal oxidation, yielding 4-Hydroxy alprazolam.
    4-Hydroxy alprazolam
  • HY-136560
    6-Azathymine acid
    6-Azathymine acid is a metabolite of Pymetrozine. Pymetrozine is active against plant-sucking insects, such as aphids and whiteflies in vegetables, cotton, field crops and fruits and affects the nervous regulation of feeding behavior.
    6-Azathymine acid
  • HY-132417S
    (rac)-N,O-Didesmethyl Tramadol-d3
    (rac)-N,O-Didesmethyl Tramadol-d3 is a deuterium labeled (rac)-N,O-Didesmethyl Tramadol. (rac)-N,O-Didesmethyl Tramadol is the main metabolite of Tramadol.
    (rac)-N,O-Didesmethyl Tramadol-d<sub>3</sub>
  • HY-136345
    (Rac)-3′-Hydroxy simvastatin
    		99.71%
    (Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
    (Rac)-3′-Hydroxy simvastatin
  • HY-Y1117S2
    Melamine-15N3,13C3
    Melamine-15N3,13C3 is a 13C- and 15N-labeled Melamine (HY-Y1117). Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials.
    Melamine-<sup>15</sup>N<sub>3</sub>,<sup>13</sup>C<sub>3</sub>
  • HY-B0794A
    AZ7550 hydrochloride
    		98.66%
    AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
    AZ7550 hydrochloride
  • HY-N10322
    2-Hydroxyemodin
    		99.74%
    2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system.
    2-Hydroxyemodin
  • HY-130239
    14(S)-HDHA
    		≥98.0%
    14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway.
    14(S)-HDHA
  • HY-148225
    Fulvestrant 3-β-D-Glucuronide
    Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer.
    Fulvestrant 3-β-D-Glucuronide
  • HY-136612
    DCBA
    		99.65%
    DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET.
    DCBA
  • HY-132995
    DP-1
    		99.66%
    DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity.
    DP-1
Cat. No. Product Name / Synonyms Application Reactivity